Southend could include new loan signing striker Waide Fairhurst in the starting line-up.
Defender Bilel Mohsni begins a three-match ban, while strikers Blair Sturrock and Barry Corr are doubtful.
Southend United manager Paul Sturrock told BBC Essex: "They played very, very well [in Wednesday's penalty shoot-out defeat by Sheffield Wednesday]. Anyone who watched the game will see they have a quality team there.
"They're playing in a brand new stadium on a brand new pitch where they're undefeated all season.
"So they're a very difficult opposition to play against."
Source: BBC Sport