New Northampton boss Gary Johnson has three new faces after starting with a 3-2 home defeat against Shrewsbury.
Town have signed Wolves left-back Jamie Reckord, as well as Steve Collis and Seth Nana Ofori-Twumasi from Johnson's former club Peterborough, all on loan.
Spireites boss John Sheridan's policy of playing Jack Lester in home games is likely to see the veteran striker return to the starting XI.
Source: BBC Sport
