Crewe manager Dario Gradi could hand striker Ajay Leitch-Smith his first start of the season, after scoring twice in three substitute appearances.
Winger Joel Grant could be the only doubt after being substituted in the 1-1 draw with Macclesfield in midweek.
Crewe manager Dario Gradi told BBC Radio Stoke: "We'll obviously have to consider Ajay, we've been talking about it all week.
"He can do no more than he's done; he's come on and scored two goals and barely played half an hour so he's staked a real claim for a place.
"Macclesfield at home, getting a point, isn't the greatest result but Chesterfield away is a different matter all together. Having said that, we want to score some goals."
Source: BBC Sport